Histone methyltransferase: Difference between revisions
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Michal Harel (talk | contribs) New page: '''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to ly... |
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{{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | |||
'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. | |||
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== 3D Structures of histone methyltransferase == | |||
[[1nw3]] – hHMT DOT1L – human | [[1nw3]] – hHMT DOT1L – human | ||
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[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM | [[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM | ||
[[Category:Topic Page]] | |||
Revision as of 00:37, 30 September 2011
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
3D Structures of histone methyltransferase3D Structures of histone methyltransferase
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
3rib – hKHMT Smyd2 + SAH
3s7b - hKHMT Smyd2 + SAM + inhibitor