Histone: Difference between revisions
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{{STRUCTURE_2hue| PDB=2hue | SIZE=400| SCENE= |right|CAPTION=Yeast H3, H4 and anti-silencing protein complex with sulfate, glycerol and Zn+2 ion, [[2hue]] }} | {{STRUCTURE_2hue| PDB=2hue | SIZE=400| SCENE= |right|CAPTION=Yeast H3, H4 and anti-silencing protein complex with sulfate, glycerol and Zn+2 ion, [[2hue]] }} | ||
'''Histones''' (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. | '''Histones''' (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones. See details in [[nucleosomes]]. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
Revision as of 13:32, 25 August 2011
Histones (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones. See details in nucleosomes.
3D Structures of histone3D Structures of histone
HistoneHistone
1yqa – yH1 (mutant) – yeast – NMR
1uss, 1ust – yH1 globular domain - NMR
2xd7, 1zr3, 2fxk – H2A macro domain – human
1yd9 – H2A macro domain – rat
1ku5 – HPHA – Pyrococcus horikoshii
1b67, 1b6w, 1a7w, 1hta – MfHMFA – Methanococcus fervidus
1bfm – MfHB - NMR
1f1e – H – Methanopyrus kandleri
1hst – cH5 - chicken
3iid, 3iif – H2A macro domain + ADP-ribose
2g9a, 2g99, 2h13 – H3 + WD-repeat protein
Nucleosome coreNucleosome core
3r45 - hH4 + H3-like centromeric protein + Holliday junction recognition protein
3nqj, 3nqu - hH4 + H3-like centromeric protein
3qzs, 3qzt – XlH4 + nucleosome-remodeling factor subunit BPTF – Xenopus laevis
2io5 - XlH3.1 + H4 + anti-silencing protein
2yf7, 2yfw - H4 + H3-like centromeric protein + SCM3 – Kluyveromyces lactis
2l5a - yH4/H3-like centromeric protein/SCM3
2jss - yH2A/H2B + CHZ1 – NMR
2hue - yH3 + H4 + anti-silencing protein
2xql - cH3.2 + H4 + H2A + H2B – EM
Nucleosome core + DNANucleosome core + DNA
3an2 – hH4 + H2A + H2B + H3-like centromeric protein + DNA
3av1, 2av2 – hH3.2 + H4 + H2A + H2B + DNA
3a6n, 3afa, 2cv5 - hH3.1 + H4 + H2A + H2B + DNA
3mnn, 3o62, 3lz0, 3lz1, 3lel, 3kuy, 3c1b, 3c1c, 2nzd, 2fj7, 1zbb, 1s32, 1p34, 1p3a, 1p3b, 1p3f, 1p3g, 1p3i, 1p3k, 1p3l, 1p3m, 1p3o, 1p3p, 1m18, 1m19, 1m1a, 1kx3, 1kx4, 1kx5, 1aoi - XlH3.2 + H4 + H2A + H2B + DNA
2f8n - XlH3.1 + H4 + H2A + H2B + H3 + H2A macro domain + DNA
1zla – XlH3 + H4 + H2A + H2B + H3 + antigen + DNA
3mgp, 3mgq, 3mgr, 3mgs, 3lja, 3b6f, 3b6g - XlH3.2 + H4 + H2A + H2B + metal ion + DNA
3kxb - XlH3.2 (mutant) + H4 + H2A + H2B (mutant) + DNA
3kwq - XlH3.2 (mutant) + H4 + H2A + H2B + DNA
3mvd - XlH3.2 + H4 + H2A + H2B + regulator of chromosome condensation + DNA
1id3 - yH3 + H4 + H2A + H2B + DNA
2aro, 1tzy, 1hq3, 2hio, 1hio - cH3 + H4 + H2A + H2B
1eqz - cH3 + H4 + H2A + H2B + DNA
2pyo, 3nqb - H3 + H4 + H2A + H2B + DNA – Drosophila melanogaster
1u35 - mH3.1 + H2A + H2B + His2A macro domain + DNA – mouse
1f66 - XlH3 + mH4 + hH2A + XlH2B + DNA