NEDD8: Difference between revisions
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[[Image:1ndd.png|left|200px|thumb|Crystal Structure of NEDD8, [[1ndd]]]] | [[Image:1ndd.png|left|200px|thumb|Crystal Structure of NEDD8, [[1ndd]]]] | ||
{{STRUCTURE_1ndd| PDB=1ndd | SIZE=300| SCENE=NEDD8/Cv/1 |right|CAPTION=NEDD8, [[1ndd]] }} | {{STRUCTURE_1ndd| PDB=1ndd | SIZE=300| SCENE=NEDD8/Cv/1 |right|CAPTION=NEDD8 complex with sulfate and Cl ions, [[1ndd]] }} | ||
[[NEDD8]] is a ubiquitin-like protein in human. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase. In yeast the protein is called Rub1. The images at the left and at the right correspond to one representative NEDD8, ''i.e.'' the crystal structure of NEDD8 ([[1ndd]]). Cl and SO4 are shown as space filling objects. | [[NEDD8]] is a ubiquitin-like protein in human. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase. In yeast the protein is called Rub1. The images at the left and at the right correspond to one representative NEDD8, ''i.e.'' the crystal structure of NEDD8 ([[1ndd]]). Cl and SO4 are shown as space filling objects. | ||
Revision as of 11:40, 4 August 2011
NEDD8 is a ubiquitin-like protein in human. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase. In yeast the protein is called Rub1. The images at the left and at the right correspond to one representative NEDD8, i.e. the crystal structure of NEDD8 (1ndd). Cl and SO4 are shown as space filling objects.
3D Structures of NEDD83D Structures of NEDD8
NEDD8NEDD8
1ndd - hNEDD8 - human
2ko3 – hNEDD8 – NMR
NEDD8+ubiquitin-activating enzyme E1NEDD8+ubiquitin-activating enzyme E1
3gzn – hNEDD8+hE1 regulatory and catalytic subunits
3dbh, 3dbl, 3dbr - hNEDD8+hE1 regulatory and catalytic subunits (mutant)
2nvu - hNEDD8+hE1 regulatory subunit+MBP/E1 catalytic subunit+UBC12
1r4m - hNEDD8+hE1C+amyloid beta precursor protein
1r4n - hNEDD8+hE1C+amyloid beta precursor protein+ATP
NEDD8+other proteinsNEDD8+other proteins
3dqv – hNEDD8+CUL-5
2bkr – hNEDD8+NEDP1
1xt9 – hNEDD8+DEN1
Rub1Rub1
1bt0 – Rub1 – Arabidopsis thaliana