Vinculin: Difference between revisions
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== 3D Structures of Vinculin == | == 3D Structures of Vinculin == | ||
''Update June 2011'' | |||
[[3h2u]] – hVCL Vd1 + raver1 RRM<br /> | |||
[[3h2u]] – hVCL Vd1 + raver1 RRM - human<br /> | |||
[[3h2v]] - hVCL C-terminal + raver1 RRM<br /> | [[3h2v]] - hVCL C-terminal + raver1 RRM<br /> | ||
[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br /> | [[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br /> | ||
[[1tr2]] – hVCL<br /> | [[1tr2]] – hVCL<br /> | ||
[[1ydi]] - hVCL Vd1+hActinin VBS<br /> | [[1ydi]] - hVCL Vd1+hActinin VBS<br /> | ||
[[1t01]] - cVCL Vd1+mTalin VBS – | [[1t01]] - cVCL Vd1+mTalin VBS – chicken<br /> | ||
[[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br /> | [[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br /> | ||
[[1qkr]] – hVCL C-terminal<br /> | [[1qkr]] – hVCL C-terminal<br /> | ||
==Metavinculin== | |||
[[3myi]] – m-VCL tail domain <br /> | |||
[[3rf3]] - hm-VCL + invasin IPAA<br /> | |||
[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal <br /> | |||
[[1xwj]] - cm-VCL Vd1+cTalin VBS3<br /> | |||
[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL Vd1+cTalin rod<br /> | |||
[[1st6]] – cm-VCL<br /> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:30, 26 June 2011
Vinculins (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, i.e. crystal structure of human full-length Vinculin (1tr2).
3D Structures of Vinculin3D Structures of Vinculin
Update June 2011
3h2u – hVCL Vd1 + raver1 RRM - human
3h2v - hVCL C-terminal + raver1 RRM
2ibf, 2hsq, 2gww - hVCL Vd1 + SfVCL binding sites from Shigella flexneri
1tr2 – hVCL
1ydi - hVCL Vd1+hActinin VBS
1t01 - cVCL Vd1+mTalin VBS – chicken
1syq, 1rkc, 1rke – hVCL Vd1+hTalin VBS
1qkr – hVCL C-terminal
MetavinculinMetavinculin
3myi – m-VCL tail domain
3rf3 - hm-VCL + invasin IPAA
2gdc – cm-VCL Vd1+SfInvasin C-terminal
1xwj - cm-VCL Vd1+cTalin VBS3
1zvz, 1zw2, 1zw3, 1u6h - cm-VCL Vd1+cTalin rod
1st6 – cm-VCL