Phage integrase: Difference between revisions
Michal Harel (talk | contribs) New page: left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]] {{STRUCTURE_1z1g| PDB=1z1g | SIZE=300| S |right|CAPTION= Enterobacteria phage λ integ... |
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[[Image:1z1g.png|left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]]]] | [[Image:1z1g.png|left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]]]] | ||
{{STRUCTURE_1z1g| PDB=1z1g | SIZE=300| | {{STRUCTURE_1z1g| PDB=1z1g | SIZE=300| SCENE=Phage_integrase/Cv/1 |right|CAPTION= Enterobacteria phage λ integrase:DNA complex (Holiday Junction) [[1z1g]] }} | ||
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'''Phage integrase''' (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB. The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria. | '''Phage integrase''' (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB. The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria. | ||
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== 3D Structures of phage integrase == | == 3D Structures of phage integrase == | ||
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[[3bvp]] – PIN catalytic core domain – Lactococcus phage TP101-1<br /> | [[3bvp]] – PIN catalytic core domain – Lactococcus phage TP101-1<br /> | ||
[[1aih]] - PIN catalytic core domain – Haemophilus phage HP1 | [[1aih]] - PIN catalytic core domain – Haemophilus phage HP1 | ||
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Revision as of 11:39, 17 April 2011
Phage integrase (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB. The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
3D Structures of phage integrase3D Structures of phage integrase
3nrw – PIN/site-specific recombinase N-terminal – Haloarcula marismortui
3jtz – PIN arm-type binding domain – Yersinia pestis
3ju0 – HPI PIN arm-type binding domain – Pectobacterium atrosepticum
2kkp – PIN SAM-like domain – Moorella thermoacetica – NMR
2kkv – PIN fragment – Salmonella enterica – NMR
2khq - PIN fragment – Staphylococcus saprophyticus – NMR
2wcc – λPIN DBD+ DNA – Enterobacteria phage λ - NMR
1kjk – λPIN N-terminal - NMR
2oxo, 1z19, 1z1b - λPIN core binding domain + DNA
1ae9 - λPIN catalytic core domain (mutant)
1z1g – λPIN + DNA (Holliday junction)
1p7d – λPIN fragment + DNA
3bvp – PIN catalytic core domain – Lactococcus phage TP101-1
1aih - PIN catalytic core domain – Haemophilus phage HP1