Fibrinogen: Difference between revisions

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Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>).   
Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>).   


===Fibrinogen alpha+beta+gamma chains===
===Fibrinogen α+β+γ chains===


==== Human ====
[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br />
hFba + hFbb + hFbg:
[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]]
[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
<br />
[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
hFba + hFbb + hFbg + knobs A & B:
[[1jy3]], [[1deq]] – cFba+cFbb+cFbg – cow<br />
[[3ghg]], [[2q9i]], [[2z4e]]
[[1jy2]] - cFba+cFbb+cFbg proteolytic fragment<br />
<br />
[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
hFba + hFbb + hFbg + peptide ligand:
[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]]  
[[1ei3]] - heFba+heFbb+heFbg<br />
<br />
hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor:
[[2a45]]  
==== Cow ====
cFba + cFbb + cFbg:
[[1jy3]], [[1deq]]<br />
cFba+cFbb+cFbg proteolytic fragment: [[1jy2]]
==== Sea lamprey ====
Fba + Fbb + Fbg + peptide ligand:
[[1n73]], [[1lwu]]  
==== Hen ====
heFba + heFbb + heFbg:
[[1ei3]]
<br />
heFba + heFbb + heFbg + peptide ligand:
[[1m1j]]


===Fibrinogen alpha chain===
===Fibrinogen α chain===


cFba: [[2baf]]<br />
[[1fzd]] – hFba EC domain<br />
cFba – NMR: [[2jor]]<br />
[[1bbr]] – hFba+cε-thrombin<br />
hFba EC domain: [[1fzd]] <br />
[[2jor]] – cFba – NMR<br />
[[2baf]] – cFba<br />


===Fibrinogen beta chain===
===Fibrinogen β chain===


hFb fragment D: [[1fze]], [[1fza]], [[1fzb]]<br />
[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
hFb fragment double-D + peptide ligand: [[1fzf]], [[1fzg]]<br />
[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />


===Fibrinogen gamma chain===
===Fibrinogen γ chain===
 
[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
[[2fib]], 3fib - hFbg+peptide ligand<br />
[[1fib]] – hFbg+Ca<br />
[[1fic]], [[1fid]] – hFbg<br />
[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
[[2hwl]] – hFbg peptide+prothrombin<br />


hFbg: [[1fic]], [[1fid]] <br />
hFbg + Ca: [[1fib]]<br />
hFbg + peptide ligand: [[2fib]], [[3fib]] <br />
hFbg + SaClumping Factor A – ''Staphylococcus aureus'': [[2vr3]]<br />
hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] <br />


==References==
==References==

Revision as of 15:44, 2 February 2011

File:3hus2.jpg
Crystal Structure of Fibrinogen with peptide ligand, 3hus

Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, 3hus

Drag the structure with the mouse to rotate

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]


3D Structure of Fibrinogen3D Structure of Fibrinogen

Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).

Fibrinogen α+β+γ chainsFibrinogen α+β+γ chains

3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg – cow
1jy2 - cFba+cFbb+cFbg proteolytic fragment
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg

Fibrinogen α chainFibrinogen α chain

1fzd – hFba EC domain
1bbr – hFba+cε-thrombin
2jor – cFba – NMR
2baf – cFba

Fibrinogen β chainFibrinogen β chain

1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D

Fibrinogen γ chainFibrinogen γ chain

2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid – hFbg
1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum
2hwl – hFbg peptide+prothrombin


ReferencesReferences

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

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