Vinculin: Difference between revisions
No edit summary |
No edit summary |
||
| Line 10: | Line 10: | ||
[[3myi]] – m-VCL tail domain – human<br /> | [[3myi]] – m-VCL tail domain – human<br /> | ||
[[3h2u]] – hVCL Vd1 + raver1 RRM<br /> | [[3h2u]] – hVCL Vd1 + raver1 RRM<br /> | ||
[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from Shigella flexneri<br /> | [[3h2v]] - hVCL C-terminal + raver1 RRM<br /> | ||
[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br /> | |||
[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal – chicken<br /> | [[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal – chicken<br /> | ||
[[1tr2]] – hVCL<br /> | [[1tr2]] – hVCL<br /> | ||
Revision as of 10:23, 2 January 2011
Vinculins (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, i.e. crystal structure of human full-length Vinculin (1tr2).
3D Structures of Vinculin3D Structures of Vinculin
3myi – m-VCL tail domain – human
3h2u – hVCL Vd1 + raver1 RRM
3h2v - hVCL C-terminal + raver1 RRM
2ibf, 2hsq, 2gww - hVCL Vd1 + SfVCL binding sites from Shigella flexneri
2gdc – cm-VCL Vd1+SfInvasin C-terminal – chicken
1tr2 – hVCL
1xwj - cm-VCL Vd1+cTalin VBS3
1zvz, 1zw2, 1zw3, 1u6h - cm-VCL Vd1+cTalin rod
1ydi - hVCL Vd1+hActinin VBS
1t01 - cVCL Vd1+mTalin VBS – mouse
1st6 – cm-VCL
1syq, 1rkc, 1rke – hVCL Vd1+hTalin VBS
1qkr – hVCL C-terminal