Talin

File:2x0c.png

Crystal Structure of Talin 2x0c

Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, i.e. the crystal structure of mouse Talin rod (2x0c).

3D Structures of Talin3D Structures of Talin

Talin subdomainsTalin subdomains

2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
2kma – mTal F0F1 – NMR
2kc1 - mTal F0 – NMR
2kc2 - mTal F1 – NMR
2hrj - cTal F2 – NMR
1mix – cTal F2F3
2kgx – mTal F3+mTal fragment – NMR
3ivf – mTal FERM domain

Integrin binding sitesIntegrin binding sites

2jsw, 2qdq – mTal IBS – NMR
3g9w – mTal F2F3+integrin tail
1miz, 1mk7, 1mk9 - hTal+integrin tail
2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
3fyq – Tal rod IBS2 – Drosophila melanogaster

Vinculin binding sitesVinculin binding sites

2kvp, 2b0h – mTal VBS3 – NMR
1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
1u6h - cTal VBS2+ vinculin head
1t01 - cTal VBS1+ vinculin head
1syq - hTal VBS1+ vinculin head – human
1rkc - hTal VBS3+ vinculin head
1u89 - mTal VBS2 – NMR

PIP kinase binding sitesPIP kinase binding sites

1y19 - mTal F2F3+ PIP kinase C-terminal
2g35 - mTal F3+PIP kinase peptide – NMR

Layilin binding sitesLayilin binding sites

2k00 - cTal F3+layilin fragment – NMR