Nucleoporin

File:1xip.png

Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, 1xip

Template:STRUCTURE 1xip Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, i.e. crystal structure of yeast Nucleoporin NUP159 from Saccharomyces cerevisiae (1xip),

3D Structures of Nucleoporin3D Structures of Nucleoporin

3n7c – NUP2 RANBD – Ashbya gossypii
3mmy – hNUP98 fragment+mRNA export factor – human
2q5x, 2q5y – hNUP98 C-terminal
2ec1 – hNUP50 RANBD
1ko6 – hNUP98 C-terminal
3i4r, 3cqc, 3cqg – hNUP107+NUP133
1xks – hNUP133 N-terminal
3bg0, 3bg1 – hNUP145+Sec13-related protein
3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN
2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR
1xip – yNUP159 N-terminal
3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase
2oit – hNUP214 N-terminal
1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN C-terminal
1xke - hNUP358 RANBD - NMR
3kfo – yNUP133 C-terminal –yeast
2c1t – yNUP2 N-terminal+importrin alpha subunit
2aiv – yNUP116 C-terminal - NMR
3kep, 3kes – yNUP145 autoproteolytic domain
3jro, 3iko – yNUP84+NUP145+protein Sec13
3jrp - yNUP145+protein Sec13
3f7f, 3h7n, 3hxr – yNUP120
3i5p, 3i5q – yNUP170
3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1
2bpt – yNUP1P+importin beta subunit
1un0 – yNUP2P N-terminal+importrin alpha subunit
2rfo, 2qx5 – yNic96
2k0c – rNUP153 RANBD– rat – NMR
2osz – rNUP58/45
2c1m – mNUP50 N-terminal+importin – mouse
1wwh – mNUP35 MPPN domain