Fibrinogen: Difference between revisions
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cFba + cFbb + cFbg: | cFba + cFbb + cFbg: | ||
[[1jy3]], [[1deq]] | [[1jy3]], [[1deq]] | ||
cFba+cFbb+cFbg proteolytic fragment: [[1jy2]] | |||
==== Sea lamprey ==== | ==== Sea lamprey ==== | ||
Fba + Fbb + Fbg + peptide ligand: | Fba + Fbb + Fbg + peptide ligand: | ||
Revision as of 15:26, 20 December 2010
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]
3D Structure of Fibrinogen3D Structure of Fibrinogen
Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).
Fibrinogen alpha+beta+gamma chainsFibrinogen alpha+beta+gamma chains
HumanHuman
hFba + hFbb + hFbg:
1re4, 1rf0, 1n8e, 1lt9
hFba + hFbb + hFbg + knobs A & B:
3ghg, 2q9i, 2z4e
hFba + hFbb + hFbg + peptide ligand:
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj
hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor:
2a45
CowCow
cFba + cFbb + cFbg: 1jy3, 1deq cFba+cFbb+cFbg proteolytic fragment: 1jy2
Sea lampreySea lamprey
Fba + Fbb + Fbg + peptide ligand: 1n73, 1lwu
HenHen
heFba + heFbb + heFbg:
1ei3
heFba + heFbb + heFbg + peptide ligand:
1m1j
Fibrinogen alpha chainFibrinogen alpha chain
cFba: 2baf
cFba – NMR: 2jor
hFba EC domain: 1fzd
Fibrinogen beta chainFibrinogen beta chain
hFb fragment D: 1fze, 1fza, 1fzb
hFb fragment double-D + peptide ligand: 1fzf, 1fzg
Fibrinogen gamma chainFibrinogen gamma chain
hFbg: 1fic, 1fid
hFbg + Ca: 1fib
hFbg + peptide ligand: 2fib, 3fib
hFbg + SaClumping Factor A – Staphylococcus aureus: 2vr3
hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: 2vdo, 2vdp, 2vdq, 2vdr
ReferencesReferences
- ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
- ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233