Vinculin: Difference between revisions
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{{STRUCTURE_1tr2| PDB=1tr2 | SIZE=300| SCENE=Vinculin/Cv/2 |right|CAPTION=Human full-length Vinculin, [[1tr2]] }} | {{STRUCTURE_1tr2| PDB=1tr2 | SIZE=300| SCENE=Vinculin/Cv/2 |right|CAPTION=Human full-length Vinculin, [[1tr2]] }} | ||
[[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, ''i.e.'' crystal structure of human full-length Vinculin ([[1tr2]]). | [[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, ''i.e.'' crystal structure of human full-length Vinculin ([[1tr2]]). | ||
Revision as of 12:46, 16 December 2010
Vinculins (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, i.e. crystal structure of human full-length Vinculin (1tr2).
3D Structures of Vinculin3D Structures of Vinculin
3myi – m-VCL tail domain – human
3h2u – hVCL Vd1 + raver1 RRM
2ibf, 2hsq, 2gww - hVCL Vd1 + SfVCL binding sites from Shigella flexneri
2gdc – cm-VCL Vd1+SfInvasin C-terminal – chicken
1tr2 – hVCL
1xwj - cm-VCL Vd1+cTalin VBS3
1zvz, 1zw2, 1zw3, 1u6h - cm-VCL Vd1+cTalin rod
1ydi - hVCL Vd1+hActinin VBS
1t01 - cVCL Vd1+mTalin VBS – mouse
1st6 – cm-VCL
1syq, 1rkc, 1rke – hVCL Vd1+hTalin VBS
1qkr – hVCL C-terminal