Pharmaceutical Drug Targets and Diseases

AstraZeneca’s Nexium

The following is a list of major pharmaceutical compound targets, drugs, and information organized by disease.

• • Alzheimer’s Disease
    • Acetylcholine
    • Acetylcholinesterase
    • Acetylcholinesterase from Torpedo Californica
    • Flexibility of Aromatic Residues in AChE
    • Beta Amyloid
    • Acetylcholine binding protein (AChBP)
    • Butyrylcholinesterase (BChE)
    • Drug Compounds & Substrates
      • Bivalent Inhibitors of Acetylcholinesterase
      • Bivalent Inhibitors of Acetylcholinesterase, Part II
      • Inhibitors and Substrates of Acetylcholinesterase
      • Inhibitors and Substrates of Acetylcholinesterase, Part II
      • Inhibitors and Substrates of Acetylcholinesterase, Part III
      • Specific Examples:
        • Aricept Complexed with Acetylcholinesterase
        • DFP (Aged) Complexed with Acetylcholinesterase
        • Edrophonium Complexed with Acetylcholinesterase or Here
        • Fluorophore Thioflavin T Complexed with Acetylcholinesterase
        • Galanthamine Complexed with Acetylcholinesterase
        • Huperzine A Complexed with Acetylcholinesterase
        • Iminium Galanthamine Derivative bound to Acetylcholinesterase or Here, or Here.
        • NAP Complexed with Acetylcholinesterase
        • O-tthylmethylphosphonylated Acetylcholinesterase
        • Soman Complexed with Acetylcholinesterase or Here, or Here, or Here, or Here.
        • Tacrine Complexed with Acetylcholinesterase
      • Bivalent Inhibitors
        • Anticancer Prodrug CPT-11 Complexed with Acetylcholinesterase
        • Aricept Complexed with Acetylcholinesterase
        • Bis-Acting Galanthamine Derivative Complexed with Acetylcholinesterase, or Here, or Here
        • Bis-Tacrine Derivative Complexed with Acetylcholinesterase or Here or Here
        • Bisquaternary Decamethonium Complexed with Acetylcholinesterase
        • BW284C51 Complexed with Acetylcholinesterase
        • Hupyridone Derivative Complexed with Acetylcholinesterase, or Here, or Here, or Here
        • N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE Complexed with Acetylcholinesterase
        • PEG-SH Complexed with Acetylcholinesterase
    • Gamma-Secratase
    • Glutamate Receptor
      • Glutamate receptor (GluA2)
      • Glutamate Receptor
  • Anemia
    • Erythropoietin
  • Asthma and other Pulmonary Disease States
    • Beta-2-Andrenergic Receptor
    • Leukotriene Receptor
  • Atherosclerosis & Hypercholesterolemia
    • HMG-CoA Reductase
    • 5-Lipoxygenase Activating Protein
  • Autoimmune Diseases
    • Tumor Necrosis Factor Receptor
    • Tumor-Necrosis Factor Apoptosis-Inducing Ligand
  • Bacterial Infections
    • Gyrase - Target of the Quinolones
    • Interactions between Antibiotics & the Ribosome
    • Large Ribosomal Subunit
    • Large Ribosomal Subunit with Azithromycin
    • PcrA Helicase
  • Blood Clots, Haemophilia, & Thrombic Events
    • P2Y12
    • Haemophilia
      • Factor VII
      • Factor IX
      • Factor IX Bound to Antibody
      • Factor Xa
  • Cancer
    • Antizyme Inhibitor
    • Caspases
      • Caspase-6
      • Caspase-7 Dynamics
      • Caspase-9 Regulation
    • Cisplatin Information
    • Cyclin Dependent Kinase Inhibitor
    • Cytochrome P450 Oxidoreductase
    • DEBS
    • Dihydrofolate Reductase, the Target of Methotrexate
    • Farnesoid X Receptor
    • Growth Factors & Receptors
      • Epidermal Growth Factor
        • Epidermal Growth Factor
        • Epidermal Growth Factor Receptor
      • Hepatocyte Growth Factor Receptor
      • Human Epidermal Growth Factor Receptor 2
      • Insulin-Like Growth Factor
        • Insulin-Like Growth Factor-1
        • Insulin-Like Growth Factor-1 Receptor
      • Vascular Growth Factor
        • Vascular Endothelial Growth Factor
        • Vascular Endothelial Growth Factor Receptor
    • Hypoxia Inducible Factor (HIF)
    • Heat Shock Protein 90
    • Human 8-Oxoguanine Glycosylase Structure and Mechanism (HOGG1)
    • Kinases
      • Cyclin Dependent Kinase-4
      • Cell Division Cycle 7-Related Protein Kinase
      • Mammalian Target of Rapamycin
      • Mitogen-Activated Proteins
        • Mitogen-Activated Protein Kinase
        • Mitogen-Activated Protein Kinase Kinase
        • Mitogen-Activated Protein Kinase Kinase Kinase
          • c-Raf
      • Phosphatidylinositol 3-Kinase
      • SRC
    • MDM2 Bound to p53
    • P-Glycoprotein: Why Cancer Drugs Fail
    • Oncogenes
      • C-Myc - Proto-Oncogenic Gene
      • P53 - Tumor Suppressing Gene
      • SRC - Proto-Oncogenic Tyrosine Kinase Gene
    • Proteins in Cancer
    • Ras Superfamily
    • Retinoblastoma Protein
    • Taxol Information
    • Tumor-Necrosis Factor Apoptosis-Inducing Ligand
    • YKL-40
  • Compromised Immune System
    • Granulocyte-macrophage colony-stimulating factor
  • Delivery Systems
    • Targeted Drug Delivery
  • Diabetes & Hypoglycemia
    • Insulin Information
    • Insulin Structure
    • Leptin
    • Peroxisome Proliferator-Activated Receptors
    • YKL-40
  • Digestive Diseases
    • Proton Pump
  • Erectile Dysfunction
    • cGMP-Specific Phosphodiesterase Type 5
  • Hypertension & Congestive Heart Failure
    • Angiotensin-Converting Enzyme
    • Calcium Channel
  • Inflammation & Rheumatoid Arthritis
    • Cyclooxygenase
    • Asprin Effects on Cyclooxygenase
    • YKL-40
  • Metabolic Disorders
    • Acid-beta-glucosidase
    • ß-2 Microglobulin
    • Protective Protein/Cathepsin A (PPCA)
    • Protective Protein/Cathepsin A (PPCA) 2
    • Thiolase
    • Treatment_of_Gaucher_disease
    • Velaglucerase
    • Velaglucerase Disulfide Connectivity
  • Schizophrenia, Bipolar Depression, Insomnia, and Anxiety Disorders
    • Dopamine Receptor
    • Andrenergic Receptor
    • Histamine Receptor
    • Opioid Receptor
  • Viral Infection
    • T7 RNA Polymerase
    • HIV
      • HIV-1 Drug
      • HIV-1 Protease
      • HIV-1 Protease Analysis
      • HIV-1 Gag
      • HIV-1 Gag N-terminal Domain
      • HIV-1 Gag Recruitment of Tsg101 and the Viral Budding Process
      • HIV-1 NEF
      • HIV-1 Protease Inhibitor
      • HIV-1 Subtype C Protease
      • Reverse Transcriptase
    • Influenza
      • Avian Influenza Neuraminidase, Tamiflu and Relenza
      • Avian Influenza Neuraminidase, Tamiflu and Relenza
      • H1N1 Sequence Analyses
        • • H1N1 Swine Flu Sequence Analysis
          • H1N1 Swine Flu Multiple Sequence Alignment
          • H1N1 Sequence Alignment of MP2 Protein
          • H1N1 Sequence Alignment of PB2 Protein
          • H1N1 Sequence Alignment of PB1 Protein
          • H1N1 Sequence Alignment of NS2 Protein
          • H1N1 Sequence Alignment of PA Protein
          • H1N1 Sequence Alignment of HA Protein
          • H1N1 Sequence Alignment of NP Protein
          • H1N1 Sequence Alignment of NA Protein
          • H1N1 Sequence Alignment of MP Protein
          • H1N1 Sequence Alignment of NS Protein
      • Hemagglutinins
      • Influenza hemagglutinin
      • Influenza A M2 Transmembrane Domain
      • Proton Channels featuring a morph of the M2 proton channel of influenza.
      • Tamiflu
      • Relenza
    • Herpes Simplex Virus Thymidine Kinase
    • RNA Dependent RNA Polymerase from Hepatitis C Virus