Villin: Difference between revisions
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[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]] | [[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]] | ||
{{STRUCTURE_2k6n| | {{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }} | ||
Villin (VIL) is an actin-binding protein. The images at the top and at the right correspond to one representative Villin structure, ''i.e.'' human supervillin headpiece ([[2k6n]]). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. <ref>PMID:10480879</ref> Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the [[Gelsolin]] superfamily which is expressed in the peripheral sensory neurons. | Villin (VIL) is an actin-binding protein. The images at the top and at the right correspond to one representative Villin structure, ''i.e.'' human supervillin headpiece ([[2k6n]]). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. <ref>PMID:10480879</ref> Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the [[Gelsolin]] superfamily which is expressed in the peripheral sensory neurons. | ||
Revision as of 10:14, 26 July 2010
Villin (VIL) is an actin-binding protein. The images at the top and at the right correspond to one representative Villin structure, i.e. human supervillin headpiece (2k6n). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. [1] Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the Gelsolin superfamily which is expressed in the peripheral sensory neurons.
3D Structures of Villin3D Structures of Villin
SupervillinSupervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
VillinVillin
3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
AdvillinAdvillin
1und – hAVIL headpiece