Fibrinogen: Difference between revisions
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[[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]] | [[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]] | ||
<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/ | <applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | ||
'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref> | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref> | ||
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==3D Structure of Fibrinogen== | ==3D Structure of Fibrinogen== | ||
Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) . | Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene> ) . | ||
===Fibrinogen alpha+beta+gamma chains=== | ===Fibrinogen alpha+beta+gamma chains=== | ||
Revision as of 08:52, 26 July 2010
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing Knobs A & B to form fibrin. [1] It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. [2]
3D Structure of Fibrinogen3D Structure of Fibrinogen
Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (, , ) .
Fibrinogen alpha+beta+gamma chainsFibrinogen alpha+beta+gamma chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg - cow
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg
Fibrinogen alpha chainFibrinogen alpha chain
1fzd – hFba EC domain
2jor – cFba – NMR
2baf – cFba
Fibrinogen beta chainFibrinogen beta chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D
Fibrinogen gamma chainFibrinogen gamma chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid - hFbg
ReferencesReferences
- ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
- ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233