3en4: Difference between revisions

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[[Image:3en4.png|left|200px]]
[[Image:3en4.png|left|200px]]


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===Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor===
===Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor===


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{{ABSTRACT_PUBMED_18849971}}
{{ABSTRACT_PUBMED_18849971}}


==About this Structure==
==About this Structure==
3EN4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EN4 OCA].  
[[3en4]] is a 2 chain structure of [[Proto-oncogene tyrosine-protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EN4 OCA].  
 
==See Also==
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:18849971</ref><references group="xtra"/>
<ref group="xtra">PMID:018849971</ref><references group="xtra"/>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Knight, Z A.]]
[[Category: Knight, Z A.]]
[[Category: Shokat, K M.]]
[[Category: Shokat, K M.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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[[Category: Tyrosine]]
[[Category: Tyrosine]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:57:56 2009''

Revision as of 17:53, 26 July 2012

File:3en4.png

Template:STRUCTURE 3en4

Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitorTargeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor

Template:ABSTRACT PUBMED 18849971

About this StructureAbout this Structure

3en4 is a 2 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Gallus gallus. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. Epub 2008 Oct 12. PMID:18849971 doi:http://dx.doi.org/10.1038/nchembio.117

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