2zyb: Difference between revisions

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{{Seed}}
[[Image:2zyb.png|left|200px]]
[[Image:2zyb.jpg|left|200px]]


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{{STRUCTURE_2zyb|  PDB=2zyb  |  SCENE=  }}  
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===Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)===
===Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)===


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{{ABSTRACT_PUBMED_18977146}}
{{ABSTRACT_PUBMED_18977146}}


==Disease==
==About this Structure==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
[[2zyb]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYB OCA].


==About this Structure==
==See Also==
2ZYB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYB OCA].
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
*[[Tyrosine kinase|Tyrosine kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:18977146</ref><references group="xtra"/>
<ref group="xtra">PMID:018977146</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Tsuji, E.]]
[[Category: Tsuji, E.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Chromosomal rearrangement]]
[[Category: Cytoplasm]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Host-virus interaction]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Proto-oncogene]]
[[Category: Proto-oncogene]]
[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  4 11:25:06 2009''

Revision as of 13:08, 27 July 2012

File:2zyb.png

Template:STRUCTURE 2zyb

Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Template:ABSTRACT PUBMED 18977146

About this StructureAbout this Structure

2zyb is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. Ozawa T, Tsuji E, Ozawa M, Handa C, Mukaiyama H, Nishimura T, Kobayashi S, Okazaki K. The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase. Bioorg Med Chem. 2008 Dec 15;16(24):10311-8. Epub 2008 Oct 22. PMID:18977146 doi:10.1016/j.bmc.2008.10.041

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