Cyclic GMP-AMP synthase: Difference between revisions
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The <scene name='59/591942/Cv/4'>2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS</scene>.<ref>PMID:24462292</ref> | The <scene name='59/591942/Cv/4'>2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS</scene>.<ref>PMID:24462292</ref> | ||
==3D structures of cyclic GMP-AMP | ==3D structures of cyclic GMP-AMP structures== | ||
[[Cyclic GMP-AMP synthase 3D structures]] | [[Cyclic GMP-AMP synthase 3D structures]] | ||
Latest revision as of 12:44, 12 February 2025
FunctionCyclic GMP-AMP synthase (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway. [1] DiseaseMice lacking CGAS are more vulnerable to lethal infection by DNA virus. Structural highlightsThe .[2] 3D structures of cyclic GMP-AMP structuresCyclic GMP-AMP synthase 3D structures
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ReferencesReferences
- ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
- ↑ Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014, Jan 23. PMID:24462292 doi:http://dx.doi.org/10.1016/j.celrep.2014.01.003