Nuclear receptor coactivator: Difference between revisions

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*'''NCOA3''' shows histone acetyltransferase activity.<br />
*'''NCOA3''' shows histone acetyltransferase activity.<br />
*'''NCOA5''' is both a DNA transcription coactivator and corepressor.  It interacts with steroid receptor.<br />
*'''NCOA5''' is both a DNA transcription coactivator and corepressor.  It interacts with steroid receptor.<br />
*'''NCOA7''' may be a driver for beast cancer metastasis<ref>PMID:38699661</ref><br />
See also: [[Glucocorticoids]] and [[Steroid Hormones and their receptors]].<br />.
See also: [[Glucocorticoids]] and [[Steroid Hormones and their receptors]].<br />.
== Structural highlights ==  
== Structural highlights ==  

Latest revision as of 12:31, 17 July 2024


Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors[1].

  • NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response.
  • NCOA2 is a DNA transcription coactivator with glucocorticoid receptor.
  • NCOA3 shows histone acetyltransferase activity.
  • NCOA5 is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.
  • NCOA7 may be a driver for beast cancer metastasis[2]

See also: Glucocorticoids and Steroid Hormones and their receptors.
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Structural highlights

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  • . Water molecules are shown as red spheres.
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Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, 1oj5

Drag the structure with the mouse to rotate

3D structures of nuclear receptor coactivator3D structures of nuclear receptor coactivator

Updated on 17-July-2024

2c52 – hNCOA1 residues 920-970 + CREB-binding protein – human
1kbh, 6es7, 6sqc – hNCOA3 1040-1086 + CREB-binding protein – NMR
1v95 – hNCOA5 anticodon binding domain 197-313 – human – NMR
8arp – hNCOA7 781-942
1oj5 – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse
5y7w - mNCOA1A Pas-B domain + YL-2 peptide

ReferencesReferences

  1. ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
  2. ↑ Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Oncol Lett. 2024 Apr 23;27(6):278. PMID:38699661 doi:10.3892/ol.2024.14411

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