NADPH dehydrogenase: Difference between revisions

Revision as of 13:24, 15 July 2024

Function

NADPH dehydrogenase or old yellow enzyme or NADH:flavin oxidoreductase/NADH oxidase or prostaglandin F2A synthase or chromate reductase (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor^[1]. See NAD(P)H. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN.

NADPH dehydrogenase quinone 1 (NQO1) reduces quinones to hydroquinones.

Structural highlights

^[2]. Water molecules are shown as red spheres.

Structure of yeast NADPH dehydrogenase complex with FMN, p-hydroxybenzaldehyde and Mg+2 ion (green) (PDB code 1k03).

Drag the structure with the mouse to rotate

3D Structures of NADPH dehydrogenase3D Structures of NADPH dehydrogenase

Updated on 15-July-2024

ReferencesReferences

↑ Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488
↑ Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488

[2] Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200

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@@ Line 3: / Line 3: @@
 == Function ==
-'''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>.  See  [[NAD(P)H]].  The acceptor is a quinone.  OYE is a flavoenzyme with two cofactors: FAD and FMN.  '''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones.
+'''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>.  See  [[NAD(P)H]].  The acceptor is a quinone.  OYE is a flavoenzyme with two cofactors: FAD and FMN.
+*'''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones.
 == Structural highlights ==
 <scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres.