Nonstructural protein: Difference between revisions

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<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
__TOC__
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro).  For homology model and multiple sequence alignment see<br />
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro).  For homology model and multiple sequence alignment see<br />
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS]]<br />

Latest revision as of 10:49, 2 April 2024

Nonstructural protein (NS) is a protein encoded by a virus which is not part of the viral particle[1]. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see

For NS1 of SARS-CoV-2 see SARS-CoV-2 protein NSP1.

For NS2 of SARS-CoV-2 see SARS-CoV-2 protein NSP2.
For NS3 of SARS-CoV-2 see SARS-CoV-2 enzyme Papain-like.
For NS4 of SARS-CoV-2 see SARS-CoV-2 protein NSP4.
For NS6 of SARS-CoV-2 see SARS-CoV-2 protein NSP6.
For NS7 or replicase polyprotein 1ab light chain of SARS-CoV-2 see SARS-CoV-2 protein NSP7.
For NS8 or replicase polyprotein 1ab heavy chain of SARS-CoV-2 see SARS-CoV-2 protein NSP8.
For NS9 of SARS-CoV-2 see SARS-CoV-2 protein NSP9.
For NS10 or replicase polyprotein 1ab of SARS-CoV-2 see SARS-CoV-2 protein NSP10.
For NS12 of SARS-CoV-2 see also Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi.
For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see SARS-CoV-2 enzyme RdRp.
SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called replication-transcription complex.
For NS16+NS10 of SARS-CoV-2 see SARS-CoV-2 enzyme 2'-O-MT.

Relevance

The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See Bailey Dove/Victrelis.

Structural highlights

[2].

3D Structures of Nonstructural protein

Nonstructural protein 3D structures


Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. Epub 2013 Feb 6. PMID:23405236 doi:http://dx.doi.org/10.1371/journal.pone.0055920
  2. ↑ Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14;278(11):9489-95. Epub 2002 Dec 30. PMID:12509436 doi:10.1074/jbc.M209397200

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