SARS-CoV-2 protein NSP2

Function

Non-structural protein 2 (nsp2)

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.^[1]^[2].

Structure Determination

The structure was determined by a combination of CryoEM and AI by the QBI Coronavrus Research Group (QCRG).

ReferencesReferences

↑ Modeling of the SARS-COV-2 Genome
↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

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Jaime Prilusky, Joel L. Sussman

[1] Modeling of the SARS-COV-2 Genome

[2] Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

[1]

[2]

SARS-CoV-2 protein NSP2

Function

Structure Determination

See also

ReferencesReferences

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SARS-CoV-2 protein NSP2

Function

Structure Determination

See also

ReferencesReferences

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