4j6p: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4j6p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J6P FirstGlance]. <br> | <table><tr><td colspan='2'>[[4j6p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J6P FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6p OCA], [https://pdbe.org/4j6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j6p RCSB], [https://www.ebi.ac.uk/pdbsum/4j6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6p ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6p OCA], [https://pdbe.org/4j6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j6p RCSB], [https://www.ebi.ac.uk/pdbsum/4j6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6p ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
Latest revision as of 18:37, 20 September 2023
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form F)Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form F)
Structural highlights
FunctionFCER2_HUMAN Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Publication Abstract from PubMedIgE antibodies play a central role in allergic disease. They recognize allergens via their Fab regions, whilst their effector functions are controlled through interactions of the Fc region with two principal cell surface receptors, FcvarepsilonRI and CD23. Crosslinking of FcvarepsilonRI-bound IgE on mast cells and basophils by allergen initiates an immediate inflammatory response, while the interaction of IgE with CD23 on B-cells regulates IgE production. We have determined the structures of the C-type lectin "head" domain of CD23 from seven crystal forms. The thirty-five independent structures reveal extensive conformational plasticity in two loops that are critical for IgE binding. Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.,Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ Mol Immunol. 2013 Aug 6;56(4):693-697. doi: 10.1016/j.molimm.2013.07.005. PMID:23933509[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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