CD23

Function

CD23 or low affinity immunoglobulin epsilon Fc receptor or Fc fragment of IgE receptor II is a low affinity receptor of IgE and serves as an adhesion molecule involved in cell-cell interaction^[1]. (4gko).

Disease

CD23 may be involved in the proliferation of leukemic B cells^[2].

Relevance

CD23 is considered important in the differentiation of chronic lymphocytic leukemia^[3].

Human CD23 (magenta/blue) with IgE (pink/yellow) and Ca+2 ions (green) 4gko

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3D Structures of CD233D Structures of CD23

Updated on 20-January-2025

2h2r, 4g96, 4g9a, 4j6j, 4j6k, 4j6l, 4j6m, 4j6n, 4j6p, 4j6q – hCD23 lectin domain 156-298 – human
1t8c, 1t8d – hCD23 lectin domain – NMR
2h2t, 4gi0, 4gj0, 4gjx, 4gk1, 6y0l, 6y0m – hCD23 lectin domain (mutant)
4gko, 4ki1, 4ezm – hCD23 lectin domain + IgE-Fc
6pwr, 6pws, 6pwt – CD23 lectin domain - bovine

ReferencesReferences

↑ Bonnefoy JY, Lecoanet-Henchoz S, Gauchat JF, Graber P, Aubry JP, Jeannin P, Plater-Zyberk C. Structure and functions of CD23. Int Rev Immunol. 1997;16(1-2):113-28. doi: 10.3109/08830189709045705. PMID:9651788 doi:http://dx.doi.org/10.3109/08830189709045705
↑ Sarfati M. CD23 and chronic lymphocytic leukemia. Blood Cells. 1993;19(3):591-6; discussion 597-9. PMID:8018941
↑ DiRaimondo F, Albitar M, Huh Y, O'Brien S, Montillo M, Tedeschi A, Kantarjian H, Lerner S, Giustolisi R, Keating M. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002 Mar 15;94(6):1721-30. PMID:11920534

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Michal Harel, Joel L. Sussman, Alexander Berchansky

[1] Bonnefoy JY, Lecoanet-Henchoz S, Gauchat JF, Graber P, Aubry JP, Jeannin P, Plater-Zyberk C. Structure and functions of CD23. Int Rev Immunol. 1997;16(1-2):113-28. doi: 10.3109/08830189709045705. PMID:9651788 doi:http://dx.doi.org/10.3109/08830189709045705

[2] Sarfati M. CD23 and chronic lymphocytic leukemia. Blood Cells. 1993;19(3):591-6; discussion 597-9. PMID:8018941

[3] DiRaimondo F, Albitar M, Huh Y, O'Brien S, Montillo M, Tedeschi A, Kantarjian H, Lerner S, Giustolisi R, Keating M. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002 Mar 15;94(6):1721-30. PMID:11920534

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