3psn: Difference between revisions
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<StructureSection load='3psn' size='340' side='right'caption='[[3psn]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='3psn' size='340' side='right'caption='[[3psn]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3psn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3psn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3lh7 3lh7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PSN FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id=' | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psn OCA], [https://pdbe.org/3psn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psn RCSB], [https://www.ebi.ac.uk/pdbsum/3psn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psn OCA], [https://pdbe.org/3psn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psn RCSB], [https://www.ebi.ac.uk/pdbsum/3psn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VPS29_MOUSE VPS29_MOUSE] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro). | |||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Chhabra S]] | |||
[[Category: Chhabra | [[Category: Collins B]] | ||
[[Category: Collins | [[Category: Ghai R]] | ||
[[Category: Ghai | [[Category: Norwood S]] | ||
[[Category: Norwood | [[Category: Shaw D]] | ||
[[Category: Shaw | [[Category: Swarbrick J]] | ||
[[Category: Swarbrick | [[Category: Valkov E]] | ||
[[Category: Valkov | |||
Latest revision as of 20:07, 1 November 2023
Crystal structure of mouse VPS29 complexed with Mn2+Crystal structure of mouse VPS29 complexed with Mn2+
Structural highlights
FunctionVPS29_MOUSE Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro). See Also |
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