3nvi: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 3: Line 3:
<StructureSection load='3nvi' size='340' side='right'caption='[[3nvi]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='3nvi' size='340' side='right'caption='[[3nvi]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nvi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nvi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVI FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nmu|3nmu]], [[3nvk|3nvk]], [[3nvm|3nvm]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.709&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF0060 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU]), PF1367, rpl7ae ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvi OCA], [https://pdbe.org/3nvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nvi RCSB], [https://www.ebi.ac.uk/pdbsum/3nvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvi OCA], [https://pdbe.org/3nvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nvi RCSB], [https://www.ebi.ac.uk/pdbsum/3nvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).
[https://www.uniprot.org/uniprot/Q8U4M1_PYRFU Q8U4M1_PYRFU]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Box C/D small nucleolar and Cajal body ribonucleoprotein particles (sno/scaRNPs) direct site-specific 2'-O-methylation of ribosomal and spliceosomal RNAs and are critical for gene expression. Here we report crystal structures of an archaeal box C/D RNP containing three core proteins (fibrillarin, Nop56/58, and L7Ae) and a half-mer box C/D guide RNA paired with a substrate RNA. The structure reveals a guide-substrate RNA duplex orientation imposed by a composite protein surface and the conserved GAEK motif of Nop56/58. Molecular modeling supports a dual C/D RNP structure that closely mimics that recently visualized by electron microscopy. The substrate-bound dual RNP model predicts an asymmetric protein distribution between the RNP that binds and methylates the substrate RNA. The predicted asymmetric nature of the holoenzyme is consistent with previous biochemical data on RNP assembly and provides a simple solution for accommodating base-pairing between the C/D guide RNA and large ribosomal and spliceosomal substrate RNAs.
 
Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle.,Xue S, Wang R, Yang F, Terns RM, Terns MP, Zhang X, Maxwell ES, Li H Mol Cell. 2010 Sep 24;39(6):939-49. PMID:20864039<ref>PMID:20864039</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3nvi" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
Line 24: Line 14:
*[[Ribosomal protein L7/L12|Ribosomal protein L7/L12]]
*[[Ribosomal protein L7/L12|Ribosomal protein L7/L12]]
*[[User:Wayne Decatur/kink-turn motif|User:Wayne Decatur/kink-turn motif]]
*[[User:Wayne Decatur/kink-turn motif|User:Wayne Decatur/kink-turn motif]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pyrfu]]
[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Li, H]]
[[Category: Li H]]
[[Category: Wang, R]]
[[Category: Wang R]]
[[Category: Xue, S]]
[[Category: Xue S]]
[[Category: Kink turn]]
[[Category: Ribosome biogenesis]]
[[Category: Transferase-rna complex]]

Latest revision as of 13:01, 14 February 2024

Structure of N-terminal truncated Nop56/58 bound with L7Ae and box C/D RNAStructure of N-terminal truncated Nop56/58 bound with L7Ae and box C/D RNA

Structural highlights

3nvi is a 6 chain structure with sequence from Pyrococcus furiosus DSM 3638. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.709Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8U4M1_PYRFU

See Also

3nvi, resolution 2.71Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3nvi&oldid=4059751"