Ribosomal protein L7/L12

Function Ribosomal protein L7 (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the L7/L12 complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7. In the archaea, the L7Ae acts as a subunit of RNase P. For more details see 15.5kD/Snu13/L7Ae. Relevance RPL7 is an auto antigen in patients suffering from systemic lupus erythematosus and other connective tissue diseases.

spinqualitylabelsall models Ribosomal protein L7/L12 (PDB code 1dd3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Ribosomal protein L73D Structures of Ribosomal protein L7

Updated on 05-January-2020

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• Ribosomal protein L7
  • 1rqu, 1rqv - EcRPL7 - Escherichia coli - NMR
    
  • 1dd3, 1dd4 - TmRPL7/L12 - Thermotoga maritima
    
  • 1rqs – EcRPL7/L12 - NMR
    
  • 1rqt - EcRPL7/L12 N-terminal – NMR
    
  • 1ctf - EcRPL7/L12 C-terminal
    
  • 3paf - MjRPL7Ae (mutant)
    
  • 1ra4, 1xbi – MjRPL7Ae – Methasnocaldococcus jannaschii
    
  • 1sds – MjRPL7Ae+box H/ACA RNA
    
  • 2fc3 – RPL7Ae – Aeropyrum pernix
    
  • 2czw – RPL7Ae – Pyrococcus horikoshii
    
  • 1pxw - RPL7Ae – Pyrococcus abyssi
    
  • 1rlg – RPL7Ae+RNA fragment – Archaeoglobus fulgidus
    
  • 3pla - RPL7Ae + pre mRNA splicing protein + fibrillarin-like methyltransferase + RNA - Sulfolobus solfataricus
    
  • 3o85 - RPL7Ae – Giardia lamblia
    
  • 3nvi – PfRPL7Ae + NOP5/NOP56 + RNA – Pyrococcus furiosus
    
  • 3nvk – PfRPL7Ae + NOP5/NOP56 + fibrillarin-like methyltransferase + RNA
• Ribosomal protein L7 in part of 50S subunit
  • 2bcw – EcRPL7/L12+EcRPL11+EF-G
    
  • 1zav, 1zaw, 1zax - TmRPL7/L12 N-terminal +RPL10