1jr9: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Virgibacillus_halodenitrificans Virgibacillus halodenitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Virgibacillus_halodenitrificans Virgibacillus halodenitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR9 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr9 OCA], [https://pdbe.org/1jr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr9 OCA], [https://pdbe.org/1jr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SODM_VIRHA SODM_VIRHA] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Active only in homodimeric state.<ref>PMID:12457847</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Virgibacillus halodenitrificans]] | [[Category: Virgibacillus halodenitrificans]] | ||
[[Category: Chang | [[Category: Chang T]] | ||
[[Category: Chang | [[Category: Chang WR]] | ||
[[Category: Gui | [[Category: Gui LL]] | ||
[[Category: Jiang | [[Category: Jiang T]] | ||
[[Category: LeGall | [[Category: LeGall J]] | ||
[[Category: Li | [[Category: Li M]] | ||
[[Category: Liang | [[Category: Liang DC]] | ||
[[Category: Liao | [[Category: Liao J]] | ||
[[Category: Liu | [[Category: Liu MY]] | ||
[[Category: Zhang | [[Category: Zhang JP]] | ||
Latest revision as of 10:15, 25 October 2023
Crystal Structure of manganese superoxide dismutases from Bacillus halodenitrificansCrystal Structure of manganese superoxide dismutases from Bacillus halodenitrificans
Structural highlights
FunctionSODM_VIRHA Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Active only in homodimeric state.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedA so-called "green protein" has been purified from a moderate halophilic eubacterium, Bacillus halodenitrificans (ATCC 49067), under anaerobic conditions. The protein, which might play an important role in denitrification, dissociates mainly into two components after exposure to air: a manganese superoxide dismutase (GP-MnSOD) and a nucleoside diphosphate kinase. As a first step in elucidating the overall structure of the green protein and the role of each component, the 2.8-A resolution crystal structure of GP-MnSOD was determined. Compared with other manganese dismutases, GP-MnSOD shows two significant characteristics. The first is that the entrance to its substrate channel has an additional basic residue-Lys38. The second is that its surface is decorated with an excess of acidic over basic residues. All these structural features may be related to GP-MnSOD's high catalytic activity and its endurance against the special cytoplasm of B. halodenitrificans. The structure of GP-MnSOD provides the basis for recognizing its possible role and assembly state in the green protein. Three-dimensional structure of manganese superoxide dismutase from Bacillus halodenitrificans, a component of the so-called "green protein".,Liao J, Liu MY, Chang T, Li M, Le Gall J, Gui LL, Zhang JP, Jiang T, Liang DC, Chang WR J Struct Biol. 2002 Sep;139(3):171-80. PMID:12457847[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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