7b53: Difference between revisions

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<StructureSection load='7b53' size='340' side='right'caption='[[7b53]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='7b53' size='340' side='right'caption='[[7b53]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7b53]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B53 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B53 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7b53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B53 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">murE, b0085, JW0083 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b53 OCA], [https://pdbe.org/7b53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b53 RCSB], [https://www.ebi.ac.uk/pdbsum/7b53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b53 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b53 OCA], [http://pdbe.org/7b53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b53 RCSB], [http://www.ebi.ac.uk/pdbsum/7b53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b53 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>
[https://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>  
 
==See Also==
*[[Mur ligase|Mur ligase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Douangamath A]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Douangamath, A]]
[[Category: Fairhead M]]
[[Category: Edwards, A M]]
[[Category: Koekemoer L]]
[[Category: Fairhead, M]]
[[Category: Krojer T]]
[[Category: Koekemoer, L]]
[[Category: Steindel M]]
[[Category: Krojer, T]]
[[Category: Talon R]]
[[Category: Structural genomic]]
[[Category: Von Delft F]]
[[Category: Steindel, M]]
[[Category: Talon, R]]
[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase drug target]]
[[Category: Biosynthetic protein]]
[[Category: Sgc]]
[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]]

Latest revision as of 15:22, 1 February 2024

Crystal structure of MurE from E.coliCrystal structure of MurE from E.coli

Structural highlights

7b53 is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MURE_ECOLI Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.[1] [2] [3]

See Also

References

  1. ↑ Michaud C, Mengin-Lecreulx D, van Heijenoort J, Blanot D. Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli. Eur J Biochem. 1990 Dec 27;194(3):853-61. PMID:2269304
  2. ↑ Abo-Ghalia M, Michaud C, Blanot D, van Heijenoort J. Specificity of the uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate synthetase from Escherichia coli. Eur J Biochem. 1985 Nov 15;153(1):81-7. PMID:3905407
  3. ↑ Gordon E, Flouret B, Chantalat L, van Heijenoort J, Mengin-Lecreulx D, Dideberg O. Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coli. J Biol Chem. 2001 Apr 6;276(14):10999-1006. Epub 2000 Dec 20. PMID:11124264 doi:http://dx.doi.org/10.1074/jbc.M009835200

7b53, resolution 1.75Å

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