7b6l: Difference between revisions
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==Crystal structure of MurE from E.coli in complex with Z57299368== | ==Crystal structure of MurE from E.coli in complex with Z57299368== | ||
<StructureSection load='7b6l' size='340' side='right'caption='[[7b6l]]' scene=''> | <StructureSection load='7b6l' size='340' side='right'caption='[[7b6l]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6L OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[7b6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B6L FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZK:(1-ethyl-1H-benzoimidazol-2-yl)-furan-2-ylmethyl-aminee'>SZK</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6l OCA], [https://pdbe.org/7b6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b6l RCSB], [https://www.ebi.ac.uk/pdbsum/7b6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6l ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref> | |||
==See Also== | |||
*[[Mur ligase|Mur ligase]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | [[Category: Arrowsmith CH]] | ||
Latest revision as of 15:22, 1 February 2024
Crystal structure of MurE from E.coli in complex with Z57299368Crystal structure of MurE from E.coli in complex with Z57299368
Structural highlights
FunctionMURE_ECOLI Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.[1] [2] [3] See AlsoReferences
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