2u2f: Difference between revisions

<table><tr><td colspan='2'>[[2u2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2U2F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2U2F FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u2f|1u2f]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2u2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2u2f OCA], [http://pdbe.org/2u2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2u2f RCSB], [http://www.ebi.ac.uk/pdbsum/2u2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2u2f ProSAT], [http://www.topsan.org/Proteins/RSGI/2u2f TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>