5y7d: Difference between revisions

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<StructureSection load='5y7d' size='340' side='right'caption='[[5y7d]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
<StructureSection load='5y7d' size='340' side='right'caption='[[5y7d]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5y7d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7D FirstGlance]. <br>
<table><tr><td colspan='2'>[[5y7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y7D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CXorf40A, CXorf40, EOLA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7d OCA], [http://pdbe.org/5y7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7d RCSB], [http://www.ebi.ac.uk/pdbsum/5y7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7d OCA], [https://pdbe.org/5y7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y7d RCSB], [https://www.ebi.ac.uk/pdbsum/5y7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CX04A_HUMAN CX04A_HUMAN]] May have an important role of cell protection in inflammation reaction.  
[https://www.uniprot.org/uniprot/EOLA1_HUMAN EOLA1_HUMAN] May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expression (PubMed:24916366).<ref>PMID:24916366</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human endothelial-overexpressed lipopolysaccharide-associated factor 1 (EOLA1) has been suggested to regulate inflammatory responses in endothelial cells by controlling expression of proteins, interleukin-6 and vascular cell adhesion molecule-1, and by preventing apoptosis. To elucidate the structural basis of the EOLA1 function, we determined its crystal structure at 1.71 A resolution and found that EOLA1 is structurally similar to an activating signal cointegrator-1 homology (ASCH) domain with a characteristic beta-barrel fold surrounded by alpha-helices. Despite its low sequence identity with other ASCH domains, EOLA1 retains a conserved 'GxKxxExR' motif in its cavity structure. The cavity harbors aromatic and polar residues, which are speculated to accommodate nucleotide molecules as do YT521-B homology (YTH) proteins. Additionally, EOLA1 exhibits a positively charged cleft, similar to those observed in YTH proteins and the ASCH protein from Zymomonas mobilis that exerts ribonuclease activity. This implies that the positively charged cleft in EOLA1 could stabilize the binding of RNA molecules. Taken together, we suggest that EOLA1 controls protein expression through RNA binding to play protective roles against endothelial cell injuries resulting from lipopolysaccharide (LPS)-induced inflammation responses.
 
Crystal Structure of Human EOLA1 Implies Its Possibility of RNA Binding.,Kim M, Park SH, Park JS, Kim HJ, Han BW Molecules. 2019 Sep 29;24(19). pii: molecules24193529. doi:, 10.3390/molecules24193529. PMID:31569543<ref>PMID:31569543</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5y7d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Han, B W]]
[[Category: Han BW]]
[[Category: Kim, H J]]
[[Category: Kim HJ]]
[[Category: Kim, M J]]
[[Category: Kim MJ]]
[[Category: Park, J S]]
[[Category: Park JS]]
[[Category: Park, S H]]
[[Category: Park SH]]
[[Category: Endothelial-overexpressed lps associated factor 1]]
[[Category: Hydrolase]]
[[Category: Pua domain]]
[[Category: Rna binding domain]]

Latest revision as of 13:21, 27 March 2024

Crystal structure of human Endothelial-overexpressed LPS associated factor 1Crystal structure of human Endothelial-overexpressed LPS associated factor 1

Structural highlights

5y7d is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.71Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EOLA1_HUMAN May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expression (PubMed:24916366).[1]

References

  1. ↑ Liu Y, Liu H, Chen W, Yang T, Zhang W. EOLA1 protects lipopolysaccharide induced IL-6 production and apoptosis by regulation of MT2A in human umbilical vein endothelial cells. Mol Cell Biochem. 2014 Oct;395(1-2):45-51. PMID:24916366 doi:10.1007/s11010-014-2110-7

5y7d, resolution 1.71Å

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