2lm7: Difference between revisions

<table><tr><td colspan='2'>[[2lm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rot41 Rot41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LM7 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kvl|2kvl]], [[3fmg|3fmg]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm7 OCA], [http://pdbe.org/2lm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lm7 RCSB], [http://www.ebi.ac.uk/pdbsum/2lm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm7 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/VP7_ROT41 VP7_ROT41]] Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved (By similarity).