Undecaprenyl pyrophosphate synthase: Difference between revisions

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**[[5xk7]] – StUPP + DMAPP <br />
**[[5xk7]] – StUPP + DMAPP <br />
**[[5xk9]] – StUPP + GSPP + DMAPP <br />
**[[5xk9]] – StUPP + GSPP + DMAPP <br />
**[[6szg]], [[6szh]] - UPP + inhibitors - ''Acinetobacter baumannii''<br />
}}
}}


Revision as of 14:41, 19 March 2020


Function

Undecaprenyl pyrophosphate synthase (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall[1]. Bisphosphonate drugs are UPP inhibitors.

Relevance

UPP inhibitors are investigated as potential antibacterials[2].

Structural highlights

The of UPP (water molecules are shown as red spheres) contains an [3].

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

Drag the structure with the mouse to rotate

3D structures of undecaprenyl pyrophosphate synthase3D structures of undecaprenyl pyrophosphate synthase

Updated on 19-March-2020

ReferencesReferences

  1. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
  2. ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
  3. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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