Tumor necrosis factor: Difference between revisions

Revision as of 13:35, 29 December 2019

Function

Tumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells^[1]. TNFβ is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase). See also TRAIL and Molecular Playground/TRAIL.

Relevance

TNF is studied as both a target and a therapeutic in malignant diseases^[2].

Structural highlights

The biological assembly of human tumor necrosis factor is (PDB entry 2az5). .

Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5)

Drag the structure with the mouse to rotate

3D Structures of tumor necrosis factor3D Structures of tumor necrosis factor

Updated on 29-December-2019

ReferencesReferences

↑ Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep;11(9):372-7. PMID:11514191
↑ Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3. PMID:19343034 doi:http://dx.doi.org/10.1038/nrc2628

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep;11(9):372-7. PMID:11514191

[2] Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3. PMID:19343034 doi:http://dx.doi.org/10.1038/nrc2628

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 <StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
 == Function ==
-'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>.  '''TNFβ''' is inhibited by interleukin 10.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
+'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>.  '''TNFβ''' is inhibited by interleukin 10.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]].
 == Relevance ==