Succinate-semialdehyde dehydrogenase: Difference between revisions
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== Function == | == Function == | ||
'''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. | '''Succinate-semialdehyde dehydrogenase''' or '''α-ketoglutaric semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. | ||
== Disease == | == Disease == | ||
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*Succinate-semialdehyde dehydrogenase | *Succinate-semialdehyde dehydrogenase | ||
**[[2w8n]], [[2w8o]] – hSSD - human <br /> | |||
**[[2w8p]] – hSSD (mutant) <br /> | |||
**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br /> | **[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br /> | ||
**[[3vz2]] – SySSD (mutant) <br /> | **[[3vz2]] – SySSD (mutant) <br /> | ||
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**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br /> | **[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br /> | ||
**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br /> | **[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br /> | ||
**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br /> | **[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br /> | ||
**[[5x5t]] – AbSSD – ''Azuspirillum brasilense'' <br /> | |||
*Succinate-semialdehyde dehydrogenase complexes | *Succinate-semialdehyde dehydrogenase complexes | ||
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**[[4oht]] – SpSSD + NADPH<br /> | **[[4oht]] – SpSSD + NADPH<br /> | ||
**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br /> | **[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br /> | ||
**[[5x5u]] – AbSSD + NAD<br /> | |||
}} | }} | ||
Revision as of 11:08, 11 February 2020
FunctionSuccinate-semialdehyde dehydrogenase or α-ketoglutaric semialdehyde dehydrogenase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism[1]. DiseaseSSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia[2]. Structural highlightsThe active site of SSD contains the and the [3]. Water molecules are shown as red spheres. .
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3D structures of succinate-semialdehyde dehydrogenase3D structures of succinate-semialdehyde dehydrogenase
Updated on 11-February-2020
ReferencesReferences
- ↑ JAKOBY WB, SCOTT EM. Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem. 1959 Apr;234(4):937-40. PMID:13654295
- ↑ Gordon N. Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). Eur J Paediatr Neurol. 2004;8(5):261-5. PMID:15341910 doi:http://dx.doi.org/10.1016/j.ejpn.2004.06.004
- ↑ Yuan Z, Yin B, Wei D, Yuan YR. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase. J Struct Biol. 2013 May;182(2):125-35. doi: 10.1016/j.jsb.2013.03.001. Epub 2013 , Mar 13. PMID:23500184 doi:10.1016/j.jsb.2013.03.001