Glyoxalase: Difference between revisions

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**[[1bh5]] – hGLO (mutant) – human<br />
**[[1bh5]] – hGLO (mutant) – human<br />
**[[1fa8]] – EcGLO – ''Escherichia coli''<br />
**[[2c21]] – GLO – ''Leishmania major''<br />
**[[1fro]] – hGLO + benzyl glutathione<br />  
**[[1fro]] – hGLO + benzyl glutathione<br />  
**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />
**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />
**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
**[[2za0]] – mGLO + methyl gerfelin – mouse<br />
**[[2za0]] – mGLO + methyl gerfelin – mouse<br />
**[[4x2a]] – mGLO + baicalein<br />
**[[4x2a]] – mGLO + baicalein<br />
Line 32: Line 29:
**[[4opn]] – mGLO + MAH<br />
**[[4opn]] – mGLO + MAH<br />
**[[4kyk]], [[4kyh]] – mGLO + drug<br />
**[[4kyk]], [[4kyh]] – mGLO + drug<br />
**[[5d7z]] – maGLO – maize<br />
**[[6bnn]], [[6bnx]], [[6bnz]] – maGLO (mutant)<br />
**[[1fa8]] – EcGLO – ''Escherichia coli''<br />
**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
**[[2c21]] – GLO – ''Leishmania major''<br />
**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />
**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />
**[[5d7z]] – GLO – maize<br />
**[[4z04]] - GLO + glutathione – ''Brucella abortus''<br />


*Glyoxalase 2
*Glyoxalase 2


**[[1qh3]] – hGLO + actate + cacodylate<br />
**[[1qh5]] – hGLO + glutathione derivative<br />
**[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
**[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
**[[2p18]] - LiGLO – ''Leishmania infantum''<br />
**[[2p18]] - LiGLO – ''Leishmania infantum''<br />
**[[1qh3]] – hGLO + actate + cacodylate<br />
**[[1qh5]] – hGLO + glutathione derivative<br />
**[[2p1e]] – LiGLO + lactate
**[[2p1e]] – LiGLO + lactate


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**[[4lru]] – GLO – ''Candida albicans''<br />
**[[4lru]] – GLO – ''Candida albicans''<br />
*Glyoxalase/bleomycin resistance protein/dioxygenase
**[[2rbb]] – GLXI (mutant) – ''Burkholderia phytofirmans''<br />
**[[4rt5]] – GLXI – ''Planctomyces limnophilus''<br />
**[[4qb5]] – GLXI – ''Albidiferax ferrireducens''<br />
**[[4n04]], [[4g6x]] – GLXI – ''Catenulispora acidiphia''<br />
**[[4mym]] – GLXI – ''Nocardioides''<br />
**[[4hc5]] – GLXI – ''Sphaerobacter thermophilus''<br />
**[[4gym]] – GLXI – ''Conexibacter woesei''<br />
**[[3vb0]] – GLXI – ''Sphingomonas wittichii''<br />
**[[3rri]] – GLXI – ''Alicyclobacillus acidocaldarius''<br />
**[[3kol]] – GLXI – ''Nostoc punctiforme''<br />
**[[3b59]] – GLXI – ''Novosphingobium aromaticivorans''<br />
**[[2rk9]] – GLXI (mutant) – ''Vibrio splendidus''<br />
**[[2rk0]] – GLXI – ''Frankia''<br />
**[[6cky]], [[5ump]], [[5umq]], [[5uhj]], [[5ujp]] – SuGLXI – ''Streptomyces uncialis''<br />
**[[6bbx]], [[5w27]], [[5umy]] – SuGLXI + antibiotic<br />
**[[5umw]], [[5umx]] – SuGLXI + riboflavin<br />
**[[5drh]], [[5d4f]], [[5cb9]], [[5c6x]], [[5c68]], [[5c4p]] – TcGLXI – ''Thermomonospora curvata''<br />
**[[5hcw]], [[5dfg]] – TcGLXI (mutant) <br />
**[[5v0f]] – TcGLXI (mutant) + roxarsone <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:53, 16 July 2019


Function

Glyoxalase (GLO) is part of the glyoxalase system which detoxifies the highly toxic methylglyoxal and other aldehydes produced by metabolism[1].

  • GLO1 or lactoylglutathione lyase catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
  • GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.

Relevance

GLO1 is a target for drugs against bacteria, protozoans and cancer[2]. The GLO system is a focus of research on metabolic control and prevention of vascular complications in diabetes and obesity[3].

Structural highlights

[4]. Water molecules are shown as red spheres.

Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) 1qin

Drag the structure with the mouse to rotate

3D structures of glyoxalase3D structures of glyoxalase

Updated on 16-July-2019

ReferencesReferences

  1. ↑ Dixon DP, Cummins L, Cole DJ, Edwards R. Glutathione-mediated detoxification systems in plants. Curr Opin Plant Biol. 1998 Jun;1(3):258-66. PMID:10066594
  2. ↑ Thornalley PJ. The glyoxalase system in health and disease. Mol Aspects Med. 1993;14(4):287-371. PMID:8277832
  3. ↑ Rabbani N, Thornalley PJ. Glyoxalase in diabetes, obesity and related disorders. Semin Cell Dev Biol. 2011 May;22(3):309-17. doi: 10.1016/j.semcdb.2011.02.015., Epub 2011 Feb 16. PMID:21335095 doi:http://dx.doi.org/10.1016/j.semcdb.2011.02.015
  4. ↑ Cameron AD, Ridderstrom M, Olin B, Kavarana MJ, Creighton DJ, Mannervik B. Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry. 1999 Oct 12;38(41):13480-90. PMID:10521255

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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