6ac1: Difference between revisions

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'''Unreleased structure'''


The entry 6ac1 is ON HOLD  until Paper Publication
==Rat Xanthine oxidoreductase, NADH bound form==
 
<StructureSection load='6ac1' size='340' side='right'caption='[[6ac1]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
Authors: Okamoto, K., Kawaguchi, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ac1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AC1 FirstGlance]. <br>
Description: Rat Xanthine oxidoreductase, NADH bound form
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6a7x|6a7x]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ac1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ac1 OCA], [http://pdbe.org/6ac1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ac1 RCSB], [http://www.ebi.ac.uk/pdbsum/6ac1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ac1 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/XDH_RAT XDH_RAT]] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.<ref>PMID:17301076</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Kawaguchi, Y]]
[[Category: Kawaguchi, Y]]
[[Category: Okamoto, K]]
[[Category: Okamoto, K]]
[[Category: Oxidoreductase]]

Revision as of 09:08, 31 July 2019

Rat Xanthine oxidoreductase, NADH bound formRat Xanthine oxidoreductase, NADH bound form

Structural highlights

6ac1 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[XDH_RAT] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.[1]

References

  1. ↑ Asai R, Nishino T, Matsumura T, Okamoto K, Igarashi K, Pai EF, Nishino T. Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase. J Biochem. 2007 Apr;141(4):525-34. Epub 2007 Feb 14. PMID:17301076 doi:10.1093/jb/mvm054

6ac1, resolution 1.77Å

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