6ac1

Rat Xanthine oxidoreductase, NADH bound formRat Xanthine oxidoreductase, NADH bound form

Structural highlights

6ac1 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.77Å
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

XDH_RAT Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.^[1]

References

↑ Asai R, Nishino T, Matsumura T, Okamoto K, Igarashi K, Pai EF, Nishino T. Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase. J Biochem. 2007 Apr;141(4):525-34. Epub 2007 Feb 14. PMID:17301076 doi:10.1093/jb/mvm054

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OCA

[1] Asai R, Nishino T, Matsumura T, Okamoto K, Igarashi K, Pai EF, Nishino T. Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase. J Biochem. 2007 Apr;141(4):525-34. Epub 2007 Feb 14. PMID:17301076 doi:10.1093/jb/mvm054

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