Cadherin: Difference between revisions
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The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by <scene name='41/417481/Cv/5'>2 Trp residues</scene> docking into the hydrophobic pocket of the neighboring CDH molecule. <ref>PMID:16564015</ref> | The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by <scene name='41/417481/Cv/5'>2 Trp residues</scene> docking into the hydrophobic pocket of the neighboring CDH molecule. <ref>PMID:16564015</ref> | ||
== 3D Structures of Cadherin == | |||
[[Cadherin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[3lnd]] – mCDH6 EC12 (mutant)<br /> | **[[3lnd]] – mCDH6 EC12 (mutant)<br /> | ||
*CDH encoded by CDH7 | |||
**[[6cgs]] – mCDH7 EC1-EC2<br /> | |||
* CDH8 | * CDH8 | ||
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**[[2a4c]], [[2a4e]] – mCDH11 EC1<br /> | **[[2a4c]], [[2a4e]] – mCDH11 EC1<br /> | ||
**[[6cgb]] - mCDH11 EC1/CDH6 EC2<br /> | |||
* CDH20 | * CDH20 | ||
**[[1zvn]] – cCDH20 EC1 – chicken<br /> | **[[1zvn]] – cCDH20 EC1 – chicken<br /> | ||
*CDH encoded by CDH22 | |||
**[[6cg7]] – mCDH20 EC1-EC2<br /> | |||
* CDH23 | * CDH23 | ||
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**[[2wcp]] - mCDH23 EC2<br /> | **[[2wcp]] - mCDH23 EC2<br /> | ||
**[[2wd0]] - mCDH23 EC1-EC2 (mutant)<br /> | **[[2wd0]] - mCDH23 EC1-EC2 (mutant)<br /> | ||
**[[5w4t]] - CDH23 EC1-EC3 - zebrafish<br /> | |||
**[[5tfm]] - mCDH23 EC6-EC8<br /> | **[[5tfm]] - mCDH23 EC6-EC8<br /> | ||
**[[5tfl]] - mCDH23 EC7-EC8<br /> | **[[5tfl]] - mCDH23 EC7-EC8<br /> | ||
**[[5vh2]] - mCDH23 EC12-EC13 (mutant)<br /> | |||
**[[5wj8]] - hCDH23 EC13-EC14<br /> | |||
**[[5wjm]] - mCDH23 EC17-EC18<br /> | |||
**[[5tfk]] - mCDH23 EC19-EC21<br /> | **[[5tfk]] - mCDH23 EC19-EC21<br /> | ||
**[[5i8d]], [[5ulu]], [[5un2]] - mCDH23 EC19-EC21 (mutant)<br /> | **[[5i8d]], [[5ulu]], [[5un2]] - mCDH23 EC19-EC21 (mutant)<br /> | ||
**[[5vvm]] - hCDH23 EC21-EC23<br /> | |||
**[[5uz8]] - mCDH23 EC22-EC24<br /> | **[[5uz8]] - mCDH23 EC22-EC24<br /> | ||
**[[5vt8]] - mCDH23 EC23-EC25<br /> | |||
**[[4apx]], [[4aq8]], [[4axw]], [[4xxw]] - mCDH23 EC1-EC2 + Prot-CDH15<br /> | **[[4apx]], [[4aq8]], [[4axw]], [[4xxw]] - mCDH23 EC1-EC2 + Prot-CDH15<br /> | ||
**[[4aqa]], [[4aqe]] - mCDH23 EC1-EC2 (mutant) + Prot-CDH15 | **[[4aqa]], [[4aqe]] - mCDH23 EC1-EC2 (mutant) + Prot-CDH15 | ||
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**[[4zt1]], [[2o72]] – hE-CDH EC1-EC2<br /> | **[[4zt1]], [[2o72]] – hE-CDH EC1-EC2<br /> | ||
**[[4zte]] – hE-CDH EC1-EC2 + inhibitor<br /> | **[[4zte]] – hE-CDH EC1-EC2 + inhibitor<br /> | ||
**[[6fek]] – hE-CDH EC1-EC2 + antibody<br /> | |||
**[[1edh]] - mE-CDH EC1-EC2+Ca<br /> | **[[1edh]] - mE-CDH EC1-EC2+Ca<br /> | ||
**[[3q2l]], [[3q2n]], [[3qrb]] - mE-CDH EC1-EC2 (mutant)<br /> | **[[3q2l]], [[3q2n]], [[3qrb]] - mE-CDH EC1-EC2 (mutant)<br /> | ||
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**[[5veb]] – hK-CDH EC5 + antibody<br /> | **[[5veb]] – hK-CDH EC5 + antibody<br /> | ||
**[[6cgu]] – mK-CDH EC1-EC2 <br /> | |||
* T-CDH membrane bound | * T-CDH membrane bound | ||
**[[3k5r]] – mT-CDH EC1-EC2<br /> | **[[3k5r]], [[6cg6]] – mT-CDH EC1-EC2<br /> | ||
**[[3k5s]] - cT-CDH EC1-EC2 <br /> | **[[3k5s]] - cT-CDH EC1-EC2 <br /> | ||
**[[3k6d]] - XlT-CDH EC1 <br /> | **[[3k6d]] - XlT-CDH EC1 <br /> | ||
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* Protocadherin | * Protocadherin | ||
**[[6bx7]] - hProt-CDH1 EC1-EC4<br /> | |||
**[[2yst]] – hProt-CDH7 EC3 – NMR<br /> | **[[2yst]] – hProt-CDH7 EC3 – NMR<br /> | ||
**[[2ee0]] - hProt-CDH9 Ca domain – NMR<br /> | **[[2ee0]] - hProt-CDH9 Ca domain – NMR<br /> | ||
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**[[1wuz]] - mProt-CDH4 EC1 – NMR<br /> | **[[1wuz]] - mProt-CDH4 EC1 – NMR<br /> | ||
**[[5cyx]] - mProt-CDH2 EC1+EC2+EC3<br /> | **[[5cyx]] - mProt-CDH2 EC1+EC2+EC3<br /> | ||
**[[5szl]] - mProt-CDH γ A1 EC1-EC4<br /> | |||
* Desmoglein | * Desmoglein | ||
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**[[5erd]] – hDes-CDH2 ectodomain<br /> | **[[5erd]] – hDes-CDH2 ectodomain<br /> | ||
**[[5eqx]] – hDes-CDH3 ectodomain<br /> | **[[5eqx]] – hDes-CDH3 ectodomain<br /> | ||
**[[6qnt]], [[6qnu]] – hDesmc2 ectodomain + adenovirus fiber protein – Cryo EM<br /> | |||
*Desmocollin | *Desmocollin | ||
Revision as of 13:32, 18 April 2019
FunctionCadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental), K-CDH (kidney). The CDH superfamily contains:
Structural highlightsThe adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by docking into the hydrophobic pocket of the neighboring CDH molecule. [2] 3D Structures of Cadherin
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3D Structures of Cadherin3D Structures of Cadherin
Updated on 18-April-2019
ReferencesReferences
- ↑ Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368
- ↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046