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==Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772== | |||
<StructureSection load='6ed7' size='340' side='right'caption='[[6ed7]], [[Resolution|resolution]] 2.43Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ed7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ED7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ED7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J4J:2-[(2-nitrophenyl)sulfanyl]acetohydrazide'>J4J</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ed7 OCA], [http://pdbe.org/6ed7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ed7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ed7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ed7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A0A0GYM0_ECOLX A0A0A0GYM0_ECOLX]] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[HAMAP-Rule:MF_00834] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]] | |||
[[Category: Large Structures]] | |||
[[Category: Brown, C M]] | |||
[[Category: Brown, E D]] | |||
[[Category: Chan, J]] | |||
[[Category: Junop, M S]] | |||
[[Category: Zlitni, S]] | [[Category: Zlitni, S]] | ||
[[Category: | [[Category: Antibiotic]] | ||
[[Category: | [[Category: Inhibitor adduct complex]] | ||
[[Category: | [[Category: Transferase-antibiotic complex]] | ||
Revision as of 08:50, 21 August 2019
Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772
Structural highlights
Function[A0A0A0GYM0_ECOLX] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[HAMAP-Rule:MF_00834] |
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