6fg8: Difference between revisions

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'''Unreleased structure'''


The entry 6fg8 is ON HOLD
==Crystal structure of the BIR3 - SERK1 complex from Arabidopsis thaliana.==
 
<StructureSection load='6fg8' size='340' side='right' caption='[[6fg8]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
Authors: Hothorn, M., Hohmann, U.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6fg8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FG8 FirstGlance]. <br>
Description: Crystal structure of the BIR3 -SERK1 complex from Arabidopsis thaliana.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lsc|4lsc]], [[6fg7|6fg7]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fg8 OCA], [http://pdbe.org/6fg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fg8 RCSB], [http://www.ebi.ac.uk/pdbsum/6fg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fg8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.<ref>PMID:11509554</ref> <ref>PMID:17693538</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hohmann, U]]
[[Category: Hohmann, U]]
[[Category: Hothorn, M]]
[[Category: Hothorn, M]]
[[Category: Ectodomain]]
[[Category: Leucine rich repeat receptor]]
[[Category: Membrane receptor]]
[[Category: Negative regulator]]
[[Category: Protein binding]]
[[Category: Pseudokinase]]
[[Category: Receptor complex]]

Revision as of 21:32, 24 January 2018

Crystal structure of the BIR3 - SERK1 complex from Arabidopsis thaliana.Crystal structure of the BIR3 - SERK1 complex from Arabidopsis thaliana.

Structural highlights

6fg8 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SERK1_ARATH] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.[1] [2]

References

  1. ↑ Shah K, Vervoort J, de Vries SC. Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation. J Biol Chem. 2001 Nov 2;276(44):41263-9. Epub 2001 Aug 16. PMID:11509554 doi:10.1074/jbc.M102381200
  2. ↑ Aker J, Hesselink R, Engel R, Karlova R, Borst JW, Visser AJ, de Vries SC. In vivo hexamerization and characterization of the Arabidopsis AAA ATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy. Plant Physiol. 2007 Oct;145(2):339-50. Epub 2007 Aug 10. PMID:17693538 doi:10.1104/pp.107.103986

6fg8, resolution 1.25Å

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