Villin

Function Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. Cytovillin (CVIL) or ezrin or villin-2 serves as intermediate between plasma membrane and actin cytoskeleton. Relevance VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID).

spinqualitylabelsall models Human supervillin headpiece, 2k6n Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Villin3D Structures of Villin

Updated on 16-October-2017

{"openlevels":0}

• Supervillin
  • 2k6m, 2k6n – hSVIL headpiece– human – NMR
    
• Villin
  • 3fg7 – hVIL gelsolin domains 4-6
    
  • 2llf - hVIL gelsolin-like domain 6 - NMR
    
  • 1unc – hVIL headpiece
    
  • 3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
    
  • 2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
    
  • 1yu5, 1qqv - cVIL headpiece
    
  • 3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL headpiece (mutant)
    
  • 5i1n, 5i1o, 5i1p, 5i1s – cVIL-1 + cVIL headpiece
    
  • 1vii, 2vik, 2vil, 4cz3, 4cz4 - cVIL headpiece - NMR
    
  • 2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
    
  • 2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
    
  • 5vnt - VIL-4 C-terminal headpiece - Arabidopsis thaliana - NMR
    
• Advillin
  • 1und – hAVIL headpiece
    
• Cytovillin or ezrin
  • 1ni2 – hCVIL N terminal
    
  • 4rm8, 4rm9 – hCVIL
    
  • 4rma – hCVIL FERM domain