Trichodiene synthase: Difference between revisions

Revision as of 19:55, 27 September 2018

Function

Trichodiene synthase (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene. TCS contains metal ion-binding motif^[1].

Structural highlights

The of TCS contains ^[2].

Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) 2q9y

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3D Structures of trichodiene synthase3D Structures of trichodiene synthase

Updated on 27-September-2018

1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium

ReferencesReferences

↑ Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326
↑ Vedula LS, Zhao Y, Coates RM, Koyama T, Cane DE, Christianson DW. Exploring biosynthetic diversity with trichodiene synthase. Arch Biochem Biophys. 2007 Oct 15;466(2):260-6. Epub 2007 Jun 28. PMID:17678871 doi:10.1016/j.abb.2007.06.016

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326

[2] Vedula LS, Zhao Y, Coates RM, Koyama T, Cane DE, Christianson DW. Exploring biosynthetic diversity with trichodiene synthase. Arch Biochem Biophys. 2007 Oct 15;466(2):260-6. Epub 2007 Jun 28. PMID:17678871 doi:10.1016/j.abb.2007.06.016

[1]

[2]

@@ Line 1: / Line 1: @@
-<StructureSection load='' size='450' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene='54/542259/Cv/1' pspeed='8'>
+<StructureSection load='' size='350' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene='54/542259/Cv/1' pspeed='8'>
 == Function ==
 '''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP).  TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene.  TCS contains metal ion-binding motif<ref>PMID:7875326</ref>.