Talin: Difference between revisions

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* Talin subdomains  
* Talin mouse subdomains: F0 1-85; F2 86-202; F3 203-405; VBS1 482-655; R4 913-1044; B 1046-1207; C 1207-1357; R7-R8 1359-1659; rod 1359-2293; dimerization 2494-2541


**[[2x0c]] – mTal rod residues 1359-1659 – mouse<br />
**[[2kc1]], [[6ba6]] - mTal F0 domain – mouse - NMR<br />
**[[5ic0]], [[2kbb]] – mTal residues 1357-1822<br />
**[[2kc2]] - mTal F2 domain – NMR<br />
**[[5ic1]] – mTal residues 1357-1822 (mutant)<br />
**[[2kma]] – mTal F1F2 domain – NMR<br />
**[[3dyj]] - mTal residues 1974-2293<br />
**[[3ivf]] – mTal FERM domain F1F2F3 <br />
**[[1sj7]], [[1sj8]] - mTal residues 482-655<br />
**[[4f7g]] - mTal F2F3 domain + rod segment domain residues 1654-1847<br />
**[[2kma]] – mTal F1F2 residues 1-202 – NMR<br />
**[[2kgx]] – mTal F3 domain + rod fragment residues 1655-1822 – NMR<br />
**[[2kc1]] - mTal F1 residues 1-85 – NMR<br />
**[[1sj7]], [[1sj8]] - mTal VBS1 domain<br />
**[[2kc2]] - mTal F2 residues 86-202 – NMR<br />
**[[5nl1]] - mTal VBS1 domain + IPAA<br />
**[[3ivf]] – mTal FERM domain F1F2F3 residues 1-400<br />
**[[2lqg]] - mTal R4 helix domain – NMR<br />
**[[2qdq]] – mTal dimerization domain residues 2494-2541<br />
**[[2l7n]] – mTal B domain – NMR<br />
**[[2l10]] – mTal C domain – NMR<br />
**[[2x0c]] – mTal rod residues 1359-1659 <br />
**[[5ic0]], [[2kbb]] – mTal triple domain residues 1357-1822<br />
**[[5ic1]] – mTal triple domain residues 1357-1822 (mutant)<br />
**[[4w8p]] - mTal R7-8 + RIAM <br />
**[[5fzt]] - mTal R7-8 + Rho GTPase activating protein 7 peptide <br />
**[[3dyj]] - mTal rod residues 1974-2293<br />
**[[2qdq]] – mTal dimerization domain<br />
**[[2mwn]] – hTal1 residues 308-400 + RIAM – human - NMR<br />
**[[2hrj]] - cTal F2 – chicken - NMR <br />
**[[2hrj]] - cTal F2 – chicken - NMR <br />
**[[1mix]] – cTal F2F3 residues 196-400<br />
**[[1mix]] – cTal F2F3 residues 196-400<br />
**[[4f7g]] - mTal F2F3 residues 206-405 + rod segment domain residues 1654-1847<br />
**[[2kgx]]– mTal F3 residues 334-402 +mTal fragment residues 1655-1822– NMR<br />
**[[2l10]] – mTal residues 1206-1357 – NMR<br />
**[[2l7n]] – mTal residues 1046-1207 – NMR<br />
**[[2lqg]] - mTal R4 helix residues 913-1044 – NMR<br />
**[[4w8p]] - mTal R7-8 residues 1359-1659 + RIAM <br />
**[[5fzt]] - mTal R7-8 residues 1359-1659 + Rho GTPase activating protein 7 peptide <br />
**[[2mwn]] – hTal1 residues 308-400 + RIAM – human - NMR<br />


* Talin integrin-binding sites  
* Talin integrin-binding sites  

Revision as of 21:02, 24 September 2018


Talin is involved in cell-cell contacts. It links integrins to actin[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

Talin residues 1359-1659 (PDB code 2x0c)

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3D Structures of Talin3D Structures of Talin

Updated on 24-September-2018

ReferencesReferences

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

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Alexander Berchansky, Michal Harel, Joel L. Sussman
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