Fibroblast growth factor: Difference between revisions
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**[[3hal]] – FGF1 - rabbit <br /> | **[[3hal]] – FGF1 - rabbit <br /> | ||
**[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br /> | **[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br /> | ||
**[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]], [[4q91]], [[4q9g]], [[4q9p]], [[4qal]], [[4qbc]], [[4qbv]], [[4qc4]] – hFGF1 (mutant) <br /> | **[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]], [[4q91]], [[4q9g]], [[4q9p]], [[4qal]], [[4qbc]], [[4qbv]], [[4qc4]], [[4yol]], [[4xki]], [[4qo3]] – hFGF1 (mutant) <br /> | ||
**[[1dzd]], [[2rq9]] – hFGF1 - NMR <br /> | **[[1dzd]], [[2rq9]] – hFGF1 - NMR <br /> | ||
**[[1dzc]] – hFGF1 (mutant) - NMR <br /> | **[[1dzc]] – hFGF1 (mutant) - NMR <br /> | ||
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**[[1q1u]] – hFGF12 (mutant) <br /> | **[[1q1u]] – hFGF12 (mutant) <br /> | ||
**[[4jq0]] – hFGF12 + calmodulin + sodium channel subunit α <br /> | |||
*FGF13 | *FGF13 | ||
**[[3hbw]] – hFGF13 <br /> | **[[3hbw]] – hFGF13 <br /> | ||
**[[4dck]] – hFGF13 + calmodulin + sodium channel subunit α <br /> | **[[4dck]], [[4jpz]] – hFGF13 + calmodulin + sodium channel subunit α <br /> | ||
*FGF18 | *FGF18 | ||
Revision as of 13:34, 15 May 2017
FunctionFibroblast growth factors (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family[1].
RelevanceFGF signaling is important in the pathogenesis of a variety of tumor types[2], angiogenesis[3] and wound healing[4]. Structural insights[5]. |
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3D structures of fibroblast growth factor3D structures of fibroblast growth factor
Updated on 15-May-2017
ReferencesReferences
- ↑ Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol. 2001;2(3):REVIEWS3005. Epub 2001 Mar 9. PMID:11276432
- ↑ Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer. 2010 Feb;10(2):116-29. doi: 10.1038/nrc2780. PMID:20094046 doi:http://dx.doi.org/10.1038/nrc2780
- ↑ Friesel RE, Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 1995 Jul;9(10):919-25. PMID:7542215
- ↑ Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33(5):381-94. PMID:12696985
- ↑ Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M. Dimerization effect of sucrose octasulfate on rat FGF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):448-52. Epub 2008 May 16. PMID:18540049 doi:10.1107/S174430910801066X