Cyclin: Difference between revisions

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<StructureSection load='3blh' size='350' side='right' caption='Cyclin T1 (green) complex with CDK9 (cyan) and TRIS  (PDB entry [[3blh]])' scene='44/442748/Cv/2'>
<StructureSection load='' size='350' side='right' caption='Cyclin T1 (green) complex with CDK9 (cyan) and TRIS  (PDB entry [[3blh]])' scene='44/442748/Cv/2'>
== Function ==
== Function ==


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**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br />
**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br />
**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5lqe]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />
**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />
**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
**[[1vyw]] - hCYCA2 C-terminal + hCDK2<br />
**[[1vyw]] - hCYCA2 C-terminal + hCDK2<br />
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**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
**[[4cjy]], [[5acb]] - hCYCK +CDK12 T160P+inhibitor<br />
**[[4un0]], [[5acb]] - hCYCK +CDK12 T160P+inhibitor<br />


*CYCT
*CYCT

Revision as of 20:25, 28 December 2017

Function

Cyclin (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs, CYCA is active in the S phase, CYCD regulate the transition from G1 to S.[1] See also Intrinsically Disordered Protein.

Structural highlights

All cyclins have an all-α helix fold and share an identical ca. 100 residue domain called 'cyclin box' which binds CDK. .[2]


Cyclin T1 (green) complex with CDK9 (cyan) and TRIS (PDB entry 3blh)

Drag the structure with the mouse to rotate

3D Structures of Cyclin3D Structures of Cyclin

Updated on 28-December-2017

ReferencesReferences

  1. ↑ Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003 Aug 11;22(33):5208-19. PMID:12910258 doi:http://dx.doi.org/10.1038/sj.onc.1206558
  2. ↑ Noble ME, Endicott JA, Brown NR, Johnson LN. The cyclin box fold: protein recognition in cell-cycle and transcription control. Trends Biochem Sci. 1997 Dec;22(12):482-7. PMID:9433129

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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