1u5t: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1u5t.jpg|left|200px]] | [[Image:1u5t.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1u5t", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_1u5t| PDB=1u5t | SCENE= }} | |||
}} | |||
'''Structure of the ESCRT-II endosomal trafficking complex''' | '''Structure of the ESCRT-II endosomal trafficking complex''' | ||
| Line 32: | Line 29: | ||
[[Category: Rusnak, A S.]] | [[Category: Rusnak, A S.]] | ||
[[Category: Sun, J.]] | [[Category: Sun, J.]] | ||
[[Category: | [[Category: Endosomal]] | ||
[[Category: | [[Category: Escrt]] | ||
[[Category: | [[Category: Protein complex]] | ||
[[Category: | [[Category: Trafficking]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:32 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 10:47, 3 May 2008
Structure of the ESCRT-II endosomal trafficking complex
OverviewOverview
The multivesicular-body (MVB) pathway delivers transmembrane proteins and lipids to the lumen of the endosome. The multivesicular-body sorting pathway has crucial roles in growth-factor-receptor downregulation, developmental signalling, regulation of the immune response and the budding of certain enveloped viruses such as human immunodeficiency virus. Ubiquitination is a signal for sorting into the MVB pathway, which also requires the functions of three protein complexes, termed ESCRT-I, -II and -III (endosomal sorting complex required for transport). Here we report the crystal structure of the core of the yeast ESCRT-II complex, which contains one molecule of the Vps protein Vps22, the carboxy-terminal domain of Vps36 and two molecules of Vps25, and has the shape of a capital letter 'Y'. The amino-terminal coiled coil of Vps22 and the flexible linker leading to the ubiquitin-binding NZF domain of Vps36 both protrude from the tip of one branch of the 'Y'. Vps22 and Vps36 form nearly equivalent interactions with the two Vps25 molecules at the centre of the 'Y'. The structure suggests how ubiquitinated cargo could be passed between ESCRT components of the MVB pathway through the sequential transfer of ubiquitinated cargo from one complex to the next.
About this StructureAbout this Structure
1U5T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the ESCRT-II endosomal trafficking complex., Hierro A, Sun J, Rusnak AS, Kim J, Prag G, Emr SD, Hurley JH, Nature. 2004 Sep 9;431(7005):221-5. Epub 2004 Aug 25. PMID:15329733 Page seeded by OCA on Sat May 3 10:47:32 2008