5uke: Difference between revisions

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'''Unreleased structure'''


The entry 5uke is ON HOLD until Paper Publication
==NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant==
 
<StructureSection load='5uke' size='340' side='right' caption='[[5uke]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5uke]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UKE FirstGlance]. <br>
Description:  
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uke OCA], [http://pdbe.org/5uke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uke RCSB], [http://www.ebi.ac.uk/pdbsum/5uke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uke ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN]] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]<ref>PMID:10383454</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Kwon, J]]
[[Category: Nicholson, L K]]
[[Category: Asthma]]
[[Category: Death domain]]
[[Category: Innate immunity]]
[[Category: Irak-m]]
[[Category: Transferase]]

Revision as of 21:24, 24 January 2018

NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutantNMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant

Structural highlights

5uke is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[IRAK3_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

[IRAK3_HUMAN] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2][1]

References

  1. ↑ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10. PMID:10383454
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