BRCA: Difference between revisions

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<StructureSection load='3coj' size='340' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains (turqouis) complex with phosphopeptide (red) (PDB code [[3coj]]) ' scene=''>
<StructureSection load='3coj' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/3' pspeed='8'>


== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
The phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>.  
The <scene name='75/750267/Cv/1'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/2'>Phosphoserine binding</scene>.  


</StructureSection>
</StructureSection>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky