Mannan-binding lectin serine protease: Difference between revisions
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<StructureSection load='3tvj' size='340' side='right' caption='Human MASP-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code [[3tvj]])' scene=''> | <StructureSection load='3tvj' size='340' side='right' caption='Human MASP-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code [[3tvj]])' scene='74/748867/Cv/1'> | ||
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== Structural highlights == | == Structural highlights == | ||
MASP-1, MASP-2 and MASP-3 are 680 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>. | MASP-1, MASP-2 and MASP-3 are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>. | ||
</StructureSection> | </StructureSection> | ||